中国药科大学药剂学专业导师介绍：沈雁

　　►个人简介
沈雁，女，副教授，药剂学博士，药剂学硕士生导师

►专业研究方向
纳米给药系统；眼部给药系统；靶向基因传递系统

►主要科研工作简介
主持国家自然科学基金青年项目1项（胞内触发式还原敏感型药物联合基因靶向共传递体的构建，81201182）；主持中央高校青年基金1项（载紫杉醇的siRNA/LMHA-PEI-PLGA自组装杂化纳米粒共传递体的构建和评价）；培育项目1项（基于胞内触发机制的还原敏感型金丝桃素联合siRNA乏氧靶向共传递系统的设计）；参与国家自然基金面上项目1项（基于CD44受体靶向的透明质酸自组装胶束型纳米粒抗肿瘤siRNA传递系统的构建和评价，81072588）；国家药典委员会质量提高计划1项（注射用辅料质量标准的建立及防护功能性检查方法的建立）；主持横向项目2项（奥硝唑注射液的研制，蛋白琥珀酸铁口服液释放度的研究）

►SCI期刊
1、Xiong Y, Jiang W, Shen Y, Li H, Sun C, Ouahab A, Tu J. A poly(γ, L-glutamic acid)-citric acid based nanoconjugate for cisplatin delivery. Biomaterials. 2012，33(29):7182-93
2、Sun C, Shen Y, Sun D, Hang T, Tu J. Method development and validation for the determination of indiquinoline tartrate, a novel kappa opioid agonist, and its related substances by high-performance liquid chromatography. J Chromatogr Sci. 2012 ,50(4):343-8
3、Shen Yan, Lu Yang, Jv Minli, Hu Jinshan, Li Qian, Tu Jiasheng. Enhancing effect of Labrasol on the intestinal absorption of ganciclovir in rats. Drug Dev Ind Pharm. 2011,37: 1415-1421.
4、Shen Yan, Wang Buhai, Lu Yang, Ouahab A, Li Qian, Tu Jiasheng. A novel tumor-targeted delivery system with hydrophobized hyaluronic acid-spermine conjugates (HHSCs) for efficient receptor-mediated siRNA delivery. Int J Pharm（SCI IF=3.6 at 2010）. 2011 Jul 29;414(1-2):233-43.
5、Shen Yan, Ji Yuanxin, Xu Shengjie, Chen Daquan, Tu Jiasheng. Multivesicular liposome formulations for the sustained delivery of ropivacaine hydrochloride: preparation, characterization, and pharmacokinetics. Drug Deliv. 2011 Jul;18(5):361-6.
6、Shen Yan, Tu Jia-sheng. Rapid, sensitive and selective liquid chromatography- tandem mass spectrometry (LC-MS/MS) method for the quantification of topically applied Azithromycin in rabbit conjunctiva tissues. Journal of Pharmaceutical and Biomedical Analysis（SCI IF=2.629 at 2009）. 2010, 52(1):99-104.
7、Shen Yan, Tu Jia-sheng. Determination of Preservatives—Benzalkonium Chloride in Clinical Ophthalmic Drops of Azithromycin by High-performance Liquid Chromatography Method. Journal of Zhejiang University SCIENCE B: Biomedicine Biotechnology, 2009 10(12):877-882. (SCI IF=1.67 at 2008)
8、Shen Yan, Tu Jia-sheng. Synthesis and Characterization of Low Molecular Weight Hyaluronic acid-based cationic Micelles for efficient siRNA delivery. Carbohydrate Polymers(SCI IF=2.66 at 2008). 2009,77(1): 95-104.（此论文获2009年中国药科大学科信必成博士论坛优秀博士研究论文奖）
9、Shen Yan, Tu Jia-sheng Preparation and ocular pharmacokinetics of ganciclovir liposomes. AAPS Journal (SCI IF=3.7 at 2007), 2007, 9(3):E371-7.

►国内核心期刊
1、沈雁，李谦，范达，李瑞珺，涂家生 疏水化阳离子透明质酸胶束介导的siRNA转染影响因素及细胞靶向性研究 中国药科大学学报 2012,43(2):124-129
2、沈雁，涂家生等 特异性抑制环氧合酶-2表达的siRNA筛选 中国现代应用药学 2012,29（5）：377-381